Your risk of experiencing seizures while taking Tramadol increases if you are also taking other drugs as well. This specially refers to the following substances that you have to tell your doctor about before starting the course of Tramadol treatment:
- MAO inhibitors like isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), or selegiline (Eldepryl, Emsam);
- antidepressants like citalopram (Celexa), amitriptyline (Elavil), desipramine (Norpramin), clomipramine (Anafranil), fluvoxamine (Luvox), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), imipramine (Tofranil), sertraline (Zoloft), nortriptyline (Pamelor) or paroxetine (Paxil).
Before starting a course of Tramadol treatment you should also inform your doctor about using the following medications if that’s the case:
- carbamazepine (Tegretol);
- warfarin (Coumadin);
- digoxin (Lanoxin, Lanoxicaps);
- ketoconazole (Nizoral);
- erythromycin (E-Mycin, E.E.S., Ery-Tab);
- rifampin (Rifadin, Rimactane, Rifater);
- St. John’s wort;
- quinidine (Quinaglute, Quinadex, Cardioquin, Quinora); or
- any medications that make you feel sleepy as a side effect
This is not a complete list of possible drug interactions for Tramadol. Make sure to check with your doctor if you are currently taking any medications. Make also sure to tell your healthcare assistant about any prescription, non-prescription, off-label, herbal or recreational substances. Interaction between these substances and Tramadol can lead to serious or even dangerous side effects so it’s in your own interest to provide your doctor with as much information as you can.
Make sure to avoid taking alcohol while being on Tramadol treatment. Combining these two substances may result in a dangerous side effect of troubled breathing. Any drugs that induce sleepiness like antidepressants, sleeping aids, cold treatments, anti-seizure medicine will have their sedative effects increased if taken with Tramadol so pay much attention when combining them. Tramadol is known to depress thinking and alertness so be very careful when performing tasks where attention is required.